HRID2194305

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

反应SMILES：COc1cc(Cn2c3ccccc3c3c(OC(C)(C)C(=O)O)cccc32)ccc1OCc1nc(-c2ccccc2)oc1C

HCID11721169

未命名化合物

PRODUCTS

产物

反应SMILES：COc1cc(Cn2c3ccccc3c3c(OC(C)(C)C(=O)[O-])cccc32)ccc1OCc1nc(-c2ccccc2)oc1C.[Na+]

HCID59571744

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

1.88 g of 2-{9-[3-methoxy-4-((5-methyl-2-phenyl-oxazole-4-yl)methoxy)-benzyl]-9H-carbazole-4-yloxy}-2-methyl-propionic acid was suspended in 30 mL of 2-propanol, and dissolved at 70° C. 3.3 mL of 1 N sodium hydroxide solution was added thereto and stirred for 0.5 hour. The reaction mixture was allowed to cool, the precipitate crystal was isolated by filtration, washed with 2-propanol, dried under reduced pressure, and 1.66 g of the subject compound was prepared as white crystal.

WORKUP

后处理

dissolutiondissolved at 70° C
temperatureto cool
customthe precipitate crystal was isolated by filtration
washwashed with 2-propanol
dry with materialdried under reduced pressure, and 1.66 g of the subject compound
customwas prepared as white crystal

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-8fcd5dc9881d420aa59061c8d9228770
来源数据集: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08329913B2
来源说明: uspto-grants-2012_12

反应SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:27]=[CH:28][C:29]=1[O:30][CH2:31][C:32]1[N:33]=[C:34]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[O:35][C:36]=1[CH3:37])[CH2:6][N:7]1[C:19]2[CH:18]=[CH:17][CH:16]=[C:15]([O:20][C:21]([CH3:26])([CH3:25])[C:22]([OH:24])=[O:23])[C:14]=2[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2.[OH-].[Na+:45]>CC(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:27]=[CH:28][C:29]=1[O:30][CH2:31][C:32]1[N:33]=[C:34]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[O:35][C:36]=1[CH3:37])[CH2:6][N:7]1[C:19]2[CH:18]=[CH:17][CH:16]=[C:15]([O:20][C:21]([CH3:26])([CH3:25])[C:22]([O-:24])=[O:23])[C:14]=2[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2.[Na+:45]