Sodium Hydroxide → sodium 2-{9-[3-methoxy-4-((5-methyl-2-phenyl-oxazole-4-yl)methoxy)-benzyl]-9H-carbazole-4-yloxy}-2-methyl-propionate

HRID 2194305Notes

Reaction equation

HRID 2194305 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:27]=[CH:28][C:29]=1[O:30][CH2:31][C:32]1[N:33]=[C:34]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[O:35][C:36]=1[CH3:37])[CH2:6][N:7]1[C:19]2[CH:18]=[CH:17][CH:16]=[C:15]([O:20][C:21]([CH3:26])([CH3:25])[C:22]([OH:24])=[O:23])[C:14]=2[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2.[OH-].[Na+:45]>CC(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:27]=[CH:28][C:29]=1[O:30][CH2:31][C:32]1[N:33]=[C:34]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[O:35][C:36]=1[CH3:37])[CH2:6][N:7]1[C:19]2[CH:18]=[CH:17][CH:16]=[C:15]([O:20][C:21]([CH3:26])([CH3:25])[C:22]([O-:24])=[O:23])[C:14]=2[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2.[Na+:45]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 117211692-{9-[3-methoxy-4-((5-methyl-2-phenyl-oxazole-4-yl)methoxy)-benzyl]-9H-carbazole-4-yloxy}-2-methyl-propionic acid

Product 1

HCID 59571744sodium 2-{9-[3-methoxy-4-((5-methyl-2-phenyl-oxazole-4-yl)methoxy)-benzyl]-9H-carbazole-4-yloxy}-2-methyl-propionate

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

1.88 g of 2-{9-[3-methoxy-4-((5-methyl-2-phenyl-oxazole-4-yl)methoxy)-benzyl]-9H-carbazole-4-yloxy}-2-methyl-propionic acid was suspended in 30 mL of 2-propanol, and dissolved at 70° C. 3.3 mL of 1 N sodium hydroxide solution was added thereto and stirred for 0.5 hour. The reaction mixture was allowed to cool, the precipitate crystal was isolated by filtration, washed with 2-propanol, dried under reduced pressure, and 1.66 g of the subject compound was prepared as white crystal.

Workup

  1. dissolutiondissolved at 70° C
  2. temperatureto cool
  3. customthe precipitate crystal was isolated by filtration
  4. washwashed with 2-propanol
  5. dry with materialdried under reduced pressure, and 1.66 g of the subject compound
  6. customwas prepared as white crystal

Sources & evidence

ORD record
ord-8fcd5dc9881d420aa59061c8d9228770
Source dataset
uspto-grants-2012_12
Patent number
US08329913B2

Reaction notes

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