Methanol → HCID 59571743, compound

HRID 2194312Notes

Reaction equation

HRID 2194312 reaction equation
[OH-].[Na+:2].O1CCCC1.CO.[CH3:10][C:11]1[O:15][C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[N:13][C:12]=1[CH2:22][O:23][C:24]1[CH:56]=[CH:55][C:27]([CH2:28][N:29]2[C:41]3[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=3[C:35]3[C:30]2=[CH:31][CH:32]=[CH:33][C:34]=3[O:42][CH2:43][C:44]2[CH:54]=[CH:53][C:47]([C:48]([O:50]CC)=[O:49])=[CH:46][CH:45]=2)=[CH:26][C:25]=1[O:57][CH3:58]>O>[CH3:10][C:11]1[O:15][C:14]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[N:13][C:12]=1[CH2:22][O:23][C:24]1[CH:56]=[CH:55][C:27]([CH2:28][N:29]2[C:41]3[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=3[C:35]3[C:30]2=[CH:31][CH:32]=[CH:33][C:34]=3[O:42][CH2:43][C:44]2[CH:45]=[CH:46][C:47]([C:48]([O-:50])=[O:49])=[CH:53][CH:54]=2)=[CH:26][C:25]=1[O:57][CH3:58].[Na+:2]

Participants

6

Reactant 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 67138479HCID 67138479, compound

Product 1

HCID 59571743HCID 59571743, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1 mL of 5 N sodium hydroxide solution was added to tetrahydrofuran:methanol=1:1(20 mL) solution of 110 mg of ethyl 4-((9-(4-((5-methyl-2-phenyloxazole-4-yl)methoxy)-3-methoxybenzyl)-9H-carbazole-5-yloxy)methyl)benzoate, and stirred at 70° C. for 1 hour. The reaction mixture was allowed to cool, and the water was added thereto. The crystalline precipitate was isolated by filtration, and washed with 2-propanol. The collected precipitate was dried under reduced pressure, and 107 mg of the subject compound was prepared as white crystal.

Workup

  1. temperatureto cool
  2. customThe crystalline precipitate was isolated by filtration
  3. washwashed with 2-propanol
  4. dry with materialThe collected precipitate was dried under reduced pressure, and 107 mg of the subject compound
  5. customwas prepared as white crystal

Sources & evidence

ORD record
ord-3c12c8d1faa24d5aa6ce0c2f7974d237
Source dataset
uspto-grants-2012_12
Patent number
US08329913B2

Reaction notes

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