HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Cyanomethyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester → Tetrahydro-pyrrolo[1,2-a]pyrazine-1,6-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Cyanomethyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester | HCID 86649878 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Tetrahydro-pyrrolo[1,2-a]pyrazine-1,6-dione | HCID 66867679 | 63.1% |
Reaction Steps
1-Cyanomethyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester (1.1 g, 6.04 mmol) was dissolved in MeOH (30 ml) and hydrogenated over PtO2 (200 mg) at 20 psi for 24 hours. After filtration of the catalyst, the solvent was removed under vacuum and the residue triturated with iPrOH to afford the title compound as a white powder (580 mg, 62% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08334286B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-a6b0968dc79a478b84af28cbee335112 |
| Source note | uspto-grants-2012_12 |