Ethyl 2-amino-5-chloro-3-hydroxybenzoate → 2-Amino-5-chloro-3-hydroxybenzoic acid

Temperature

80 °C

Ethyl 2-amino-5-chloro-3-hydroxybenzoate (3.23 g) was dissolved in 160 ml of a 3N aqueous solution of hydrochloric acid and stirred at 85° C. for 3 hours and at 80° C. for 5 days. The reaction solution was cooled to room temperature, insoluble matters were filtered off, 320 ml of a 1N aqueous solution of sodium hydroxide was added to the filtrate and the mixture was stirred at room temperature for 1 hour. The resulting precipitate was filtered, washed with pure water and dried in vacuo to give 1.55 g of 2-amino-5-chloro-3-hydroxybenzoic acid.

1. temperatureThe reaction solution was cooled to room temperature
2. filtrationinsoluble matters were filtered off
3. addition320 ml of a 1N aqueous solution of sodium hydroxide was added to the filtrate
4. stirringthe mixture was stirred at room temperature for 1 hour
5. filtrationThe resulting precipitate was filtered
6. washwashed with pure water
7. customdried in vacuo

ORD record

ord-25955cfa283840378b7e0e23c3b31448

Source dataset

uspto-grants-2012_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

USRE043481E1