Potassium Hydroxide → 4-(2-Methyl-4-m-tolylethynyl-imidazol-1-yl)-1H-pyridin-2-one

HRID 2194392Notes

Reaction equation

HRID 2194392 reaction equation
Cl[C:2]1[CH:7]=[C:6]([N:8]2[CH:12]=[C:11]([C:13]#[C:14][C:15]3[CH:16]=[C:17]([CH3:21])[CH:18]=[CH:19][CH:20]=3)[N:10]=[C:9]2[CH3:22])[CH:5]=[CH:4][N:3]=1.[OH-:23].[K+]>C(O)(C)(C)C>[CH3:22][C:9]1[N:8]([C:6]2[CH:5]=[CH:4][NH:3][C:2](=[O:23])[CH:7]=2)[CH:12]=[C:11]([C:13]#[C:14][C:15]2[CH:16]=[C:17]([CH3:21])[CH:18]=[CH:19][CH:20]=2)[N:10]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 866498812-Chloro-4-(2-methyl-4-m-tolylethynyl-imidazol-1-yl)-pyridine

Product 1

HCID 498726724-(2-Methyl-4-m-tolylethynyl-imidazol-1-yl)-1H-pyridin-2-one

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

The title compound, white solid, MS: m/e=290.1 (M+H+), was prepared in accordance with the general method of example 1a from 2-chloro-4-(2-methyl-4-m-tolylethynyl-imidazol-1-yl)-pyridine and KOH in tert-butanol.

Sources & evidence

ORD record
ord-67c74baabb46448990a40917cc4f0f0f
Source dataset
uspto-grants-2012_12
Patent number
US08334287B2

Reaction notes

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