2-Bromoethyl methyl ether → 1-(2-Methoxy-ethyl)-4-(2-methyl-4-m-tolylethynyl-imidazol-1-yl)-1H-pyridin-2-one
Reaction equation
[CH3:1][C:2]1[N:3]([C:16]2[CH:21]=[CH:20][NH:19][C:18](=[O:22])[CH:17]=2)[CH:4]=[C:5]([C:7]#[C:8][C:9]2[CH:10]=[C:11]([CH3:15])[CH:12]=[CH:13][CH:14]=2)[N:6]=1.Br[CH2:24][CH2:25][O:26][CH3:27]>>[CH3:27][O:26][CH2:25][CH2:24][N:19]1[CH:20]=[CH:21][C:16]([N:3]2[CH:4]=[C:5]([C:7]#[C:8][C:9]3[CH:10]=[C:11]([CH3:15])[CH:12]=[CH:13][CH:14]=3)[N:6]=[C:2]2[CH3:1])=[CH:17][C:18]1=[O:22]Participants
3
Procedure
The title compound, colorless resin, MS: m/e=348.3 (M+H+), was prepared in accordance with the general method of example 3 from 4-(2-Methyl-4-m-tolylethynyl-imidazol-1-yl)-1H-pyridin-2-one and 2-bromoethyl-methylether.
Sources & evidence
- ORD record
- ord-1fb4ce7fdfcd44ffa31b91c5e0078fe1
- Source dataset
- uspto-grants-2012_12
- Patent number
- US08334287B2
Reaction notes
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