Methyl iodide → HCID 58111185, compound

HRID 2194409Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:22])[N:13]([C:15]3[NH:20][C:19](=[O:21])[CH:18]=[N:17][CH:16]=3)[CH:14]=2)[CH:5]=[CH:4][N:3]=1.[CH3:23]I>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:22])[N:13]([C:15]3[N:20]([CH3:23])[C:19](=[O:21])[CH:18]=[N:17][CH:16]=3)[CH:14]=2)[CH:5]=[CH:4][N:3]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 86649884HCID 86649884, compound

Product 1

HCID 58111185HCID 58111185, compound

Procedure

The title compound, yellow cristalline solid, MS: m/e=326.1, 328.2 (M+H+), was prepared in accordance with the general method of example 3 from 6-[4-(2-chloro-pyridin-4-ylethynyl)-2-methyl-imidazol-1-yl]-1H-pyrazin-2-one and methyl iodide, along with the O-alkylation product from which it was separated by flash chromatography (gradient: EtOAc to EtOAc/MeOH 95:5).

Sources & evidence

ORD record: ord-23967abb9e8f479e8676803c2109345d
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08334287B2

Reaction notes

Loading…