Chlorodimethylsilane → HCID 86652701, compound

HRID 219442Notes

Reaction equation

HRID 219442 reaction equation
[C:1]1([C@@H:7]([NH:10][C:11](=[O:24])[C:12]2[CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[CH:15]=[C:14]([N+:21]([O-:23])=[O:22])[CH:13]=2)[CH:8]=[CH2:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:25][SiH:26]([CH3:28])[Cl:27]>ClCCl.C(O)(C)C>[C:1]1([C@@H:7]([NH:10][C:11](=[O:24])[C:12]2[CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[CH:15]=[C:14]([N+:21]([O-:23])=[O:22])[CH:13]=2)[CH2:8][CH2:9][Si:26]([Cl:27])([CH3:28])[CH3:25])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 66108ChlorodimethylsilaneHCID 86652702HCID 86652702, compound

Product 1

HCID 86652701HCID 86652701, compound

Reagents, catalysts & solvents 2

HCID 3776IsopropanolSolventHCID 6344DichloromethaneSolvent

Procedure

1 g (3.06 mmol) of amide 5 was dispersed in an inert atmosphere in 10 ml of dry dichloromethane. 12 mg of H2PtCl6.xH2O was dispersed in 0.25 ml isopropanol and the obtained brown suspension was added to the reaction mixture. Afterwards, 10 ml of dimethylchlorosilane (92 mmol) was added and the reaction mixture was stirred on a reflux temperature for six hours. The transparent yellow solution was evaporated to paste remain which was dissolved in 5 ml of dry dichloromethane and again evaporated until dry.

Workup

  1. additionthe obtained brown suspension was added to the reaction mixture
  2. customThe transparent yellow solution was evaporated
  3. dissolutionwas dissolved in 5 ml of dry dichloromethane
  4. customagain evaporated
  5. customuntil dry

Sources & evidence

ORD record
ord-feae398460f746c3bec8de64f686ea69
Source dataset
uspto-grants-2012_06
Patent number
US08202417B2

Reaction notes

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