2-Bromoethyl methyl ether → 4-[2,5-dimethyl-4-m-tolylethynyl-imidazol-1-yl]-1-(2-methoxy-ethyl)-1H-pyridin-2-one

HRID 2194432Notes

Reaction equation

HRID 2194432 reaction equation
[CH3:1][C:2]1[N:3]([C:17]2[CH:22]=[CH:21][NH:20][C:19](=[O:23])[CH:18]=2)[C:4]([CH3:16])=[C:5]([C:7]#[C:8][C:9]2[CH:10]=[C:11]([CH3:15])[CH:12]=[CH:13][CH:14]=2)[N:6]=1.Br[CH2:25][CH2:26][O:27][CH3:28]>>[CH3:1][C:2]1[N:3]([C:17]2[CH:22]=[CH:21][N:20]([CH2:25][CH2:26][O:27][CH3:28])[C:19](=[O:23])[CH:18]=2)[C:4]([CH3:16])=[C:5]([C:7]#[C:8][C:9]2[CH:10]=[C:11]([CH3:15])[CH:12]=[CH:13][CH:14]=2)[N:6]=1

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 581111894-(2,5-dimethyl-4-m-tolylethynyl-imidazol-1-yl)-1H-pyridin-2-one

Product 1

HCID 498727664-[2,5-dimethyl-4-m-tolylethynyl-imidazol-1-yl]-1-(2-methoxy-ethyl)-1H-pyridin-2-one

Procedure

The title compound, light brown solid, MS: m/e=362.3 (M+H+), was prepared in accordance with the general method of example 3 from 4-[2,5-dimethyl-4-m-tolylethynyl-imidazol-1-yl]-1H-pyridin-2-one and 2-bromoethyl-methylether.

Sources & evidence

ORD record
ord-e385306d75514e0cbdfdca68b17737f5
Source dataset
uspto-grants-2012_12
Patent number
US08334287B2

Reaction notes

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