Iodoethanol → 4-[4-(2-chloro-pyridin-4-ylethynyl)-2,5-dimethyl-imidazol-1-yl]-1-(2-hydroxy-ethyl)-1H-pyridin-2-one

HRID 2194436Notes

Reaction equation

HRID 2194436 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:23])[N:13]([C:16]3[CH:21]=[CH:20][NH:19][C:18](=[O:22])[CH:17]=3)[C:14]=2[CH3:15])[CH:5]=[CH:4][N:3]=1.I[CH2:25][CH2:26][OH:27]>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:23])[N:13]([C:16]3[CH:21]=[CH:20][N:19]([CH2:25][CH2:26][OH:27])[C:18](=[O:22])[CH:17]=3)[C:14]=2[CH3:15])[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 12225IodoethanolHCID 581111874-[4-(2-chloro-pyridin-4-ylethynyl)-2,5-dimethyl-imidazol-1-yl]-1H-pyridin-2-one

Product 1

HCID 581111884-[4-(2-chloro-pyridin-4-ylethynyl)-2,5-dimethyl-imidazol-1-yl]-1-(2-hydroxy-ethyl)-1H-pyridin-2-one

Procedure

The title compound, orange solid, MS: m/e=369.0, 371.2 (M+H+), was prepared in accordance with the general method of example 3 from 4-[4-(2-chloro-pyridin-4-ylethynyl)-2,5-dimethyl-imidazol-1-yl]-1H-pyridin-2-one and 2-iodoethanol.

Sources & evidence

ORD record
ord-0a85499b99a3468494e9d728587ae5be
Source dataset
uspto-grants-2012_12
Patent number
US08334287B2

Reaction notes

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