1-Ethynyl-3-fluorobenzene → 4-[4-(3-fluoro-phenylethynyl)-2,5-dimethyl-imidazol-1-yl]-1-methyl-1H-pyridin-2-one

HRID 2194439Notes

Reaction equation

HRID 2194439 reaction equation
I[C:2]1[N:3]=[C:4]([CH3:16])[N:5]([C:8]2[CH:13]=[CH:12][N:11]([CH3:14])[C:10](=[O:15])[CH:9]=2)[C:6]=1[CH3:7].[C:17]([C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=1)#[CH:18]>>[F:25][C:21]1[CH:20]=[C:19]([C:17]#[C:18][C:2]2[N:3]=[C:4]([CH3:16])[N:5]([C:8]3[CH:13]=[CH:12][N:11]([CH3:14])[C:10](=[O:15])[CH:9]=3)[C:6]=2[CH3:7])[CH:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 5202181-Ethynyl-3-fluorobenzeneHCID 668659954-(4-iodo-2,5-dimethyl-imidazol-1-yl)-1-methyl-1H-pyridin-2-one

Product 1

HCID 498726714-[4-(3-fluoro-phenylethynyl)-2,5-dimethyl-imidazol-1-yl]-1-methyl-1H-pyridin-2-one

Procedure

The title compound, brown waxy solid, MS: m/e=322.1 (M+H+), was prepared in accordance with the general method of example 1c from 4-(4-iodo-2,5-dimethyl-imidazol-1-yl)-1-methyl-1H-pyridin-2-one and 1-Ethynyl-3-fluoro-benzene.

Sources & evidence

ORD record
ord-2d45fe685a7c4f0b8f865e2983a19c4e
Source dataset
uspto-grants-2012_12
Patent number
US08334287B2

Reaction notes

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