Potassium Hydroxide → 6-(4-iodo-2,5-dimethyl-imidazol-1-yl)-3H-pyrimidin-4-one

HRID 2194445Notes

Reaction equation

HRID 2194445 reaction equation
F[C:2]1[CH:7]=[C:6]([N:8]2[C:12]([CH3:13])=[C:11]([I:14])[N:10]=[C:9]2[CH3:15])[N:5]=[CH:4][N:3]=1.[OH-:16].[K+]>C(O)(C)(C)C>[I:14][C:11]1[N:10]=[C:9]([CH3:15])[N:8]([C:6]2[N:5]=[CH:4][NH:3][C:2](=[O:16])[CH:7]=2)[C:12]=1[CH3:13]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 668653734-Fluoro-6-(4-iodo-2,5-dimethyl-imidazol-1-yl)-pyrimidine

Product 1

HCID 1363951526-(4-iodo-2,5-dimethyl-imidazol-1-yl)-3H-pyrimidin-4-one

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

The title compound, light yellow crystalline solid, MS: m/e=316.9 (M+H+), was prepared in accordance with the general method of example 1a by treatment of 4-fluoro-6-(4-iodo-2,5-dimethyl-imidazol-1-yl)-pyrimidine with 50% KOH in tert-butanol.

Sources & evidence

ORD record
ord-5df26ff679614090a43961b87df68ba8
Source dataset
uspto-grants-2012_12
Patent number
US08334287B2

Reaction notes

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