Phosphorus oxychloride → 5-chloro-2-(2-methoxyethyl)pyridazin-3(2H)-one

HRID 2194461Notes

Reaction equation

[CH3:1][O:2][CH2:3][CH2:4][N:5]1[C:10](=[O:11])[CH:9]=[C:8](OC)[CH:7]=[N:6]1.P(Cl)(Cl)([Cl:16])=O>>[Cl:16][C:8]1[CH:7]=[N:6][N:5]([CH2:4][CH2:3][O:2][CH3:1])[C:10](=[O:11])[CH:9]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 668656102-(2-methoxy-ethyl)-5-methoxy-2H-pyridazin-3-one

Product 1

HCID 668667375-chloro-2-(2-methoxyethyl)pyridazin-3(2H)-one

Procedure

The title compound, light yellow oil, was prepared in accordance with the general method of example 23c by treatment of 2-(2-methoxy-ethyl)-5-methoxy-2H-pyridazin-3-one with phosphorus oxychloride.

Sources & evidence

ORD record: ord-aa0c762bcfce4eb996165da46c081fa2
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08334287B2

Reaction notes

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