1-Chloro-3-ethynylbenzene → 5-[4-(3-Chloro-phenylethynyl)-2-methyl-imidazol-1-yl]-2-(2-m ethoxy-ethyl)-2H-pyridazin-3-one

HRID 2194464Notes

Reaction equation

HRID 2194464 reaction equation
I[C:2]1[N:3]=[C:4]([CH3:18])[N:5]([C:7]2[CH:12]=[N:11][N:10]([CH2:13][CH2:14][O:15][CH3:16])[C:9](=[O:17])[CH:8]=2)[CH:6]=1.[Cl:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([C:26]#[CH:27])[CH:21]=1>>[Cl:19][C:20]1[CH:21]=[C:22]([C:26]#[C:27][C:2]2[N:3]=[C:4]([CH3:18])[N:5]([C:7]3[CH:12]=[N:11][N:10]([CH2:13][CH2:14][O:15][CH3:16])[C:9](=[O:17])[CH:8]=3)[CH:6]=2)[CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 1230861-Chloro-3-ethynylbenzeneHCID 668651282-(2-methoxy-ethyl)-5-(4-iodo-2-methyl-imidazol-1-yl)-2H-pyridazin-3-one

Product 1

HCID 498727705-[4-(3-Chloro-phenylethynyl)-2-methyl-imidazol-1-yl]-2-(2-m ethoxy-ethyl)-2H-pyridazin-3-one

Procedure

The title compound, yellow crystalline solid, MS: m/e=369.2, 370.9 (M+H+), was prepared in accordance with the general method of example 21a from 5-(4-Iodo-2-methyl-imidazol-1-yl)-2-(2-methoxy-ethyl)-2H-pyridazin-3-one and 1-chloro-3-ethynyl-benzene.

Sources & evidence

ORD record
ord-89b040572f0f4694ba9e4054aea0d75f
Source dataset
uspto-grants-2012_12
Patent number
US08334287B2

Reaction notes

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