2-Chloro-4-(2-(trimethylsilyl)ethynyl)pyridine → 5-[4-(2-chloro-pyridin-4-ylethynyl)-2-methyl-imidazol-1-yl]-2-ethyl-2H-pyridazin-3-one

HRID 2194465Notes

Reaction equation

HRID 2194465 reaction equation
I[C:2]1[N:3]=[C:4]([CH3:18])[N:5]([C:7]2[CH:12]=[N:11][N:10]([CH2:13][CH2:14]OC)[C:9](=[O:17])[CH:8]=2)[CH:6]=1.[Cl:19][C:20]1[CH:25]=[C:24]([C:26]#[C:27][Si](C)(C)C)[CH:23]=[CH:22][N:21]=1>>[Cl:19][C:20]1[CH:25]=[C:24]([C:26]#[C:27][C:2]2[N:3]=[C:4]([CH3:18])[N:5]([C:7]3[CH:12]=[N:11][N:10]([CH2:13][CH3:14])[C:9](=[O:17])[CH:8]=3)[CH:6]=2)[CH:23]=[CH:22][N:21]=1

Participants

3

Reactant 2

HCID 219853912-Chloro-4-(2-(trimethylsilyl)ethynyl)pyridineHCID 668651282-(2-methoxy-ethyl)-5-(4-iodo-2-methyl-imidazol-1-yl)-2H-pyridazin-3-one

Product 1

HCID 581112025-[4-(2-chloro-pyridin-4-ylethynyl)-2-methyl-imidazol-1-yl]-2-ethyl-2H-pyridazin-3-one

Procedure

The title compound, white crystalline solid, MS: m/e=370.1, 372.1 (M+H+), was prepared in accordance with the general method of example 35 from 5-(4-Iodo-2-methyl-imidazol-1-yl)-2-(2-methoxy-ethyl)-2H-pyridazin-3-one and 2-chloro-4-trimethylsilanylethynyl-pyridine.

Sources & evidence

ORD record
ord-84f014a103454ceaaeff7bf24c9df92a
Source dataset
uspto-grants-2012_12
Patent number
US08334287B2

Reaction notes

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