HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-(2-(trimethylsilyl)ethynyl)pyridine → 5-[4-(2-chloro-pyridin-4-ylethynyl)-2-methyl-imidazol-1-yl]-2-ethyl-2H-pyridazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-(2-(trimethylsilyl)ethynyl)pyridine | HCID 21985391 | — |
| Reactant | 2-(2-methoxy-ethyl)-5-(4-iodo-2-methyl-imidazol-1-yl)-2H-pyridazin-3-one | HCID 66865128 | — |
| Product | 5-[4-(2-chloro-pyridin-4-ylethynyl)-2-methyl-imidazol-1-yl]-2-ethyl-2H-pyridazin-3-one | HCID 58111202 | — |
Reaction Steps
The title compound, white crystalline solid, MS: m/e=370.1, 372.1 (M+H+), was prepared in accordance with the general method of example 35 from 5-(4-Iodo-2-methyl-imidazol-1-yl)-2-(2-methoxy-ethyl)-2H-pyridazin-3-one and 2-chloro-4-trimethylsilanylethynyl-pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08334287B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-84f014a103454ceaaeff7bf24c9df92a |
| Source note | uspto-grants-2012_12 |