Water → 1-Methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid

2.4 g (10.4 mmol) of ethyl 1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate was dissolved in 1,4-dioxane (50 mL), and 0.65 g (15 mmol) of lithium hydroxide monohydrate and 10 mL of water were added to the solution at room temperature. The resulting mixture was stirred for 24 hours at room temperature. The reaction mixture was poured into an aqueous solution of sodium hydrogen carbonate, and the mixture was washed with ethyl acetate. The aqueous phase was acidified with citric acid, and then the mixture was extracted with chloroform. The organic phase was washed with water, dried, and concentrated. The residue thus obtained was washed with ethyl acetate, and thus 2.02 g (yield: 96%) of the title compound was obtained as light yellow crystals.

1. washthe mixture was washed with ethyl acetate
2. extractionthe mixture was extracted with chloroform
3. washThe organic phase was washed with water
4. customdried
5. concentrationconcentrated
6. customThe residue thus obtained
7. washwas washed with ethyl acetate

ORD 기록

ord-8f720b76a6684cdfb885a540b9da2f49

출처 데이터셋

uspto-grants-2012_12

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08334236B2