反应详情

温度

50 °C

1.95 g (6.3 mmol) of ethyl 1-benzyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate was dissolved in 1,4-dioxane (30 mL), and 1.31 g (9.5 mmol) of potassium carbonate and 60 mL of water were added to this solution at room temperature. The resulting mixture was stirred for 3 hours at 50° C. The solvent of the reaction mixture was distilled off under reduced pressure, and the residue was dissolved in water. Concentrated hydrochloric acid was added to make the solution acidic, and the mixture was extracted with chloroform. The organic phase was dried, filtered, and concentrated, and thus 1.71 g (yield: 97%) of the title compound was obtained as colorless crystals.

1. distillationThe solvent of the reaction mixture was distilled off under reduced pressure
2. dissolutionthe residue was dissolved in water
3. additionConcentrated hydrochloric acid was added
4. extractionthe mixture was extracted with chloroform
5. customThe organic phase was dried
6. filtrationfiltered
7. concentrationconcentrated