HCID 67009976, compound → HCID 86659346, compound

HRID 2194521Notes

Reaction equation

HRID 2194521 reaction equation
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][CH:16]=[CH:15][C:4]=1[CH2:5][NH:6][C:7]1[C:12]([CH2:13][OH:14])=[CH:11][CH:10]=[CH:9][N:8]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][CH:16]=[CH:15][C:4]=1[CH2:5][NH:6][C:7]1[N:8]=[CH:9][CH:10]=[CH:11][C:12]=1[CH:13]=[O:14]

Participants

4

Reactant 1

HCID 67009976HCID 67009976, compound

Product 1

HCID 86659346HCID 86659346, compoundYield 93%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Conditions

Temperature
60 °C

Procedure

8.03 g (32.9 mmol) of (2-(2-methoxybenzylamino)-3-pyridinyl)methanol was dissolved in chloroform (100 mL), and 8.60 g (98.7 mmol) of manganese dioxide was added thereto. The resulting mixture was stirred overnight at 60° C. The reaction mixture was filtered, and the filtrate was concentrated. Thus, 7.40 g (yield: 93%) of the title compound was obtained as an orange-colored solid.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-cc1c68a2c1cb4108a8eb1b57a8e0d7fc
Source dataset
uspto-grants-2012_12
Patent number
US08334236B2

Reaction notes

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