Hydrochloric Acid → HCID 67010394, compound

Participants

Reaction Conditions

Reaction Steps

3.00 g (8.90 mmol) of ethyl 1-(2-methoxybenzyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate was dissolved in 1,4-dioxane (90 mL), and 6 N hydrochloric acid (16 mL) was added thereto at room temperature. The resulting mixture was stirred for 5 hours at 50° C., and then the solvent was distilled off under reduced pressure from the reaction mixture. The residue was washed with water and dried, and thus 2.80 g (yield: quantitative) of the title compound was obtained as colorless crystals.

Provenance & Evidence