Hydrochloric Acid → HCID 67010394, compound

HRID 2194523Notes

Reaction equation

HRID 2194523 reaction equation
[CH3:1][O:2][C:3]1[CH:25]=[CH:24][CH:23]=[CH:22][C:4]=1[CH2:5][N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][N:14]=2)[CH:9]=[C:8]([C:16]([O:18]CC)=[O:17])[C:7]1=[O:21].Cl>O1CCOCC1>[CH3:1][O:2][C:3]1[CH:25]=[CH:24][CH:23]=[CH:22][C:4]=1[CH2:5][N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][N:14]=2)[CH:9]=[C:8]([C:16]([OH:18])=[O:17])[C:7]1=[O:21]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67010325HCID 67010325, compound

Product 1

HCID 67010394HCID 67010394, compoundYield 101.4%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
50 °C

Procedure

3.00 g (8.90 mmol) of ethyl 1-(2-methoxybenzyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate was dissolved in 1,4-dioxane (90 mL), and 6 N hydrochloric acid (16 mL) was added thereto at room temperature. The resulting mixture was stirred for 5 hours at 50° C., and then the solvent was distilled off under reduced pressure from the reaction mixture. The residue was washed with water and dried, and thus 2.80 g (yield: quantitative) of the title compound was obtained as colorless crystals.

Workup

  1. customat room temperature
  2. distillationthe solvent was distilled off under reduced pressure from the reaction mixture
  3. washThe residue was washed with water
  4. customdried

Sources & evidence

ORD record
ord-0ca67bcf5b6747b9a1790d8207a23afe
Source dataset
uspto-grants-2012_12
Patent number
US08334236B2

Reaction notes

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