HCID 67010052, compound → HCID 87235637, compound

HRID 2194531Notes

Reaction equation

HRID 2194531 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([NH:7][C:8]2[C:13]([CH2:14][OH:15])=[CH:12][CH:11]=[CH:10][N:9]=2)[CH:3]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]1[O:6][N:5]=[C:4]([NH:7][C:8]2[N:9]=[CH:10][CH:11]=[CH:12][C:13]=2[CH:14]=[O:15])[CH:3]=1

Participants

4

Reactant 1

HCID 67010052HCID 67010052, compound

Product 1

HCID 87235637HCID 87235637, compoundYield 101.5%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Conditions

Temperature
60 °C

Procedure

3.3 g (16 mmol) of (2-(5-methyl-3-isoxazolyl)amino-3-pyridinyl)methanol was dissolved in chloroform (60 mL), and 4.3 g (49 mmol) of manganese dioxide was added thereto. The resulting mixture was stirred for 48 hours at 60° C. The reaction mixture was filtered, and the filtrate was concentrated. Thus, 3.3 g of the title compound was obtained as an orange-colored viscous product (yield: quantitative).

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-c702638f78a24b1db14ac1741b8eca34
Source dataset
uspto-grants-2012_12
Patent number
US08334236B2

Reaction notes

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