Trifluoroacetic acid → HCID 178461299, compound

HRID 2194579Notes

Reaction equation

[CH3:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9]2[N:14]=[C:13]([O:15][CH2:16][CH:17]3[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]3)[C:12]([C:30]3[CH:35]=[CH:34][C:33]([N:36]4[CH2:41][CH2:40][O:39][CH2:38][CH2:37]4)=[CH:32][CH:31]=3)=[CH:11][N:10]=2)[CH2:4][CH2:3]1.C(O)(C(F)(F)F)=O>>[NH:20]1[CH2:19][CH2:18][CH:17]([CH2:16][O:15][C:13]2[C:12]([C:30]3[CH:35]=[CH:34][C:33]([N:36]4[CH2:41][CH2:40][O:39][CH2:38][CH2:37]4)=[CH:32][CH:31]=3)=[CH:11][N:10]=[C:9]([NH:8][C@H:5]3[CH2:4][CH2:3][C@@H:2]([CH3:1])[CH2:7][CH2:6]3)[N:14]=2)[CH2:22][CH2:21]1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 178451992HCID 178451992, compound

Product 1

HCID 178461299HCID 178461299, compound

Procedure

Using the procedure of Example 1 Step 4, tert-butyl 4-((2-(cis-4-methylcyclohexylamino)-5-(4-morpholinophenyl)pyrimidin-4-yloxy)methyl)piperidine-1-carboxylate was deprotected by TFA to provide the title compound. MS (ESI) m/z: Calc: 465.3 (M+). Found. 466.3 (M+1).

Sources & evidence

ORD record: ord-73e960e9331f49458c876efc8baa3cff
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08334292B1

Reaction notes

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