反应详情

To tert-butyl 3-(5-bromo-2-(cis-4-methylcyclohexylamino)pyrimidin-4-yloxy)azetidine-1-carboxylate (6.5 g, 14 mmol) in DCM (25 mL) was added TFA (4 mL). The mixture was stirred at room temperature for 4 h, diluted with DCM, washed with 1N NaOH solution, water, dried over sodium sulfate, filtered and concentrated to dryness. MS (ESI) m/z Calc. 340.1 (M+). Found: 342.1 (M++2).

1. washwashed with 1N NaOH solution, water
2. dry with materialdried over sodium sulfate
3. filtrationfiltered
4. concentrationconcentrated to dryness