3-Morpholinopropane-1-sulfonyl chloride → 5-[2-Ethoxy-5-(3-morpholinopropylsulphonamido)phenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

HRID 21946Notes

Reaction equation

HRID 21946 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:22][CH2:23][CH3:24])=[C:6]([C:8]2[NH:9][C:10](=[O:21])[C:11]3[N:16]([CH3:17])[N:15]=[C:14]([CH2:18][CH2:19][CH3:20])[C:12]=3[N:13]=2)[CH:7]=1.[O:25]1[CH2:30][CH2:29][N:28]([CH2:31][CH2:32][CH2:33][S:34](Cl)(=[O:36])=[O:35])[CH2:27][CH2:26]1>>[CH2:23]([O:22][C:5]1[CH:4]=[CH:3][C:2]([NH:1][S:34]([CH2:33][CH2:32][CH2:31][N:28]2[CH2:29][CH2:30][O:25][CH2:26][CH2:27]2)(=[O:36])=[O:35])=[CH:7][C:6]=1[C:8]1[NH:9][C:10](=[O:21])[C:11]2[N:16]([CH3:17])[N:15]=[C:14]([CH2:18][CH2:19][CH3:20])[C:12]=2[N:13]=1)[CH3:24]

Participants

3

Reactant 2

HCID 219731893-Morpholinopropane-1-sulfonyl chlorideHCID 1357385605-(5-Amino-2-ethoxyphenyl)-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

Product 1

HCID 1357385385-[2-Ethoxy-5-(3-morpholinopropylsulphonamido)phenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

Procedure

The title compound was prepared from 5-(5-amino-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one and 3-morpholinopropylsulphonyl chloride, following the procedure of Example 41, and was obtained as brown crystals (14%), m.p. 157°-159° C. Found: C,55.42; H,6.53; N,16.01. C24H34N6O5S requires C,55.58; H,6.61; N,16.21%.

Sources & evidence

ORD record
ord-b7100b06d10e4accb5845d30cfc312c8
Source dataset
uspto-grants-1995_06
Patent number
US05426107

Reaction notes

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