Hydrochloric Acid → HCID 67336662, compound

HRID 2194628Notes

Reaction equation

HRID 2194628 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][C:7]1[O:11][C:10]([NH:12][C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[N:18](C(OC(C)(C)C)=O)[N:17]=[CH:16]3)=[N:9][N:8]=1.[ClH:32]>O1CCOCC1>[ClH:32].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][C:7]1[O:11][C:10]([NH:12][C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[NH:18][N:17]=[CH:16]3)=[N:9][N:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67336906HCID 67336906, compound

Product 1

HCID 67336662HCID 67336662, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

250 mg of tert-butyl 5-[5-(3-methoxybenzyl)-1,3,4-oxadiazol-2-ylamino]-indazole-1-carboxylate are stirred in 10 ml of 4N HCl in dioxane in a screw-lid vial until the starting material has completely reacted. The reaction solution is evaporated, and the residue is stirred with ethyl acetate and filtered off with suction, giving 200 mg of 5-[5-(3-methoxybenzyl)-1,3,4-oxadiazol-2-ylamino]-1H-indazole hydrochloride (94%); MS-FAB (M+H+)=322.34; Rf (polar method): 1.687 min.

Workup

  1. customhas completely reacted
  2. customThe reaction solution is evaporated
  3. filtrationfiltered off with suction

Sources & evidence

ORD record
ord-093b6ee6ecc34d9ba3901a242e013b25
Source dataset
uspto-grants-2012_12
Patent number
US08334309B2

Reaction notes

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