Potassium Carbonate → HCID 86631604, compound

HRID 2194691Notes

Reaction equation

Br[C:2]1[S:6][C:5]([CH:7]=[O:8])=[CH:4][C:3]=1[C:9]1[C:10]([F:15])=[N:11][CH:12]=[CH:13][CH:14]=1.[CH3:16][C:17]1[O:18][CH:19]=[CH:20][C:21]=1[SH:22].C(=O)([O-])[O-].[K+].[K+]>>[F:15][C:10]1[C:9]([C:3]2[CH:4]=[C:5]([CH:7]=[O:8])[S:6][C:2]=2[S:22][C:21]2[CH:20]=[CH:19][O:18][C:17]=2[CH3:16])=[CH:14][CH:13]=[CH:12][N:11]=1

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 342862-Methyl-3-furanthiol

HCID 86631600HCID 86631600, compound

Product 1

HCID 86631604HCID 86631604, compoundYield 97%

Procedure

With 5-bromo-4-(2-fluoropyridin-3-yl)thiophene-2-carbaldehyde (250 mg) as a starting material, and using 2-methyl-3-furanthiol (0.114 mL) and potassium carbonate (193 mg), an operation similar to that of Reference Example 1 was performed to give the title compound as a pale-yellow oil (yield 271 mg, yield 97%).

Sources & evidence

ORD record: ord-ae45c50cc4c04af9a8a4f5ae25696282
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08334301B2

Reaction notes

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