1H-Indazole → HCID 25215201, compound

HRID 2194781Notes

Reaction equation

ClC1C=C(C#N)C2C=C[N:8]([C:11]3[N:12]([CH2:22][CH3:23])[C:13](=[O:21])[NH:14][C:15](=[O:20])[C:16]=3[CH:17]([CH3:19])[CH3:18])C=2C=1.N1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH:28]=[N:27]1>>[CH2:22]([N:12]1[C:11]([N:8]2[C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH:28]=[N:27]2)=[C:16]([CH:17]([CH3:18])[CH3:19])[C:15](=[O:20])[NH:14][C:13]1=[O:21])[CH3:23]

Participants

Reactant 2

HCID 92211H-Indazole

HCID 67050527HCID 67050527, compound

Product 1

HCID 25215201HCID 25215201, compound

Procedure

This compound was made by a procedure similar to that used to prepare 6-chloro-1-(3-ethyl-5-isopropyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-1H-indole-4-carbonitrile (90), except that 1H-indazole was used instead of 6-chloro-1H-indole-4-carbonitrile. LC-MS shows 299.1 (M+1). 1H NMR (300 MHz, CDCl3): δ 8.97 (br, 1H), 8.31 (s, 1H), 7.83 (d, 2H), 7.54 (m, 1H), 7.36 (m, 2H), 3.42 (m, 1H), 3.20 (m, 1H), 1.90 (m, 1H), 1.15 (dd, 6H), 1.00 (t, 3H).

Sources & evidence

ORD record: ord-1bebc98f5c664aeaa736aac4c08ae9cf
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08334295B2

Reaction notes

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