Pyrazole → HCID 25215198, compound

HRID 2194784Notes

Reaction equation

Cl[C:2]1C=C(C#N)C2C=C[N:8]([C:11]3[N:12]([CH2:22][CH3:23])[C:13](=[O:21])[NH:14][C:15](=[O:20])[C:16]=3[CH:17]([CH3:19])[CH3:18])[C:9]=2[CH:10]=1.[NH:26]1C=CC=N1>>[CH2:22]([N:12]1[C:11]([N:8]2[CH:9]=[CH:10][CH:2]=[N:26]2)=[C:16]([CH:17]([CH3:19])[CH3:18])[C:15](=[O:20])[NH:14][C:13]1=[O:21])[CH3:23]

Participants

Reactant 2

HCID 1048Pyrazole

HCID 67050527HCID 67050527, compound

Product 1

HCID 25215198HCID 25215198, compound

Procedure

This compound was made using a procedure similar to that used to prepare 6-chloro-1-(3-ethyl-5-isopropyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-1H-indole-4-carbonitrile (90), except that pyrazole was used instead of 6-chloro-1H-indole-4-carbonitrile. LC-MS shows 249.1 (M+1). 1H NMR (300 MHz, CDCl3): δ 9.36 (br, 1H), 7.81 (m, 1H), 7.58 (m, 1H), 6.54 (m, 1H), 3.38 (m, 2H), 2.04 (m, 1H), 1.17 (m, 9H).

Sources & evidence

ORD record: ord-bdc3a40c6aa44fa898581e9da563eccd
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08334295B2

Reaction notes

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