HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Bromo-2-methoxyphenyl)acetonitrile → 2-(4-Bromo-2-methoxyphenyl)-3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}propanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Bromo-2-methoxyphenyl)acetonitrile | HCID 52987748 | — |
| Reactant | 1,3-Dichloro-2-{2-[4-(iodomethyl)phenoxy]ethoxy}-5-methylbenzene | HCID 58488443 | — |
| Product | 2-(4-Bromo-2-methoxyphenyl)-3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}propanenitrile | HCID 67447833 | — |
Reaction Steps
Prepared according to the procedure described in EXAMPLE 1, step 4 using (4-bromo-2-methoxyphenyl)acetonitrile (III.4) and 1,3-dichloro-2-{2-[4-(iodomethyl)phenoxy]ethoxy}-5-methylbenzene (II.1) as starting materials. Purification by column chromatography on silica gel, eluting with Hex/Tol 50 to 75%, afforded the desired compound as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08334308B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-09b548e3c2844cfd8a4222563cea6f00 |
| Source note | uspto-grants-2012_12 |