反应详情

A reaction was performed according to the synthesis method of Intermediate 1 by using Intermediate 7 (2.0 g) and 10% palladium hydroxide/activated carbon (1.5 g). The reaction mixture was filtered through Celite, and the solvent of the filtrate was evaporated under reduced pressure. The residue was purified by column chromatography (Yamazen, n-hexane:ethyl acetate=3:1), and the solvent was evaporated under reduced pressure by using a rotary evaporator to obtain the title compound (1.5 g) (the reaction was performed in THF solvent (20 ml) for 20 hours).

1. filtrationThe reaction mixture was filtered through Celite
2. customthe solvent of the filtrate was evaporated under reduced pressure
3. customThe residue was purified by column chromatography (Yamazen, n-hexane:ethyl acetate=3:1)
4. customthe solvent was evaporated under reduced pressure
5. customa rotary evaporator