Sodium Carbonate → HCID 67500936, compound

HRID 2194965Notes

Reaction equation

HRID 2194965 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[NH:11][C:12]1[N:17]=[C:16]([C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)[C:15]([C:24]([O:26]CC)=[O:25])=[CH:14][N:13]=1.C(=O)([O-])[O-].[Na+:33].[Na+]>C(O)C.O>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[NH:11][C:12]1[N:17]=[C:16]([C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)[C:15]([C:24]([O-:26])=[O:25])=[CH:14][N:13]=1.[Na+:33]

Participants

5

Reactant 2

HCID 10340Sodium CarbonateHCID 592536665-Pyrimidinecarboxylic acid, 2-[(2-methyl-5-nitrophenyl)amino]-4-(3-pyridinyl)-, ethyl ester

Product 1

HCID 67500936HCID 67500936, compoundYield 85.4%

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 962WaterSolvent2×

Procedure

1.0 g ethyl 2-[(2-methyl-5-nitrophenyl)amino]-4-(3-pyridinyl)pyrimidine-5-carboxylate and 0.8 g sodium carbonate in 20 mL ethanol and 4 mL water is suspended. The mixture is refluxed for 4 hours by distillating the ethanol and compensating with water the volume loss. The mixture is cooled at room temperature, and the precipitate is filtrated, yielding 0.84 g of product.

Workup

  1. temperatureThe mixture is refluxed for 4 hours
  2. filtrationthe precipitate is filtrated

Sources & evidence

ORD record
ord-dd3c89627a6a46599f792335ca77dfbf
Source dataset
uspto-grants-2012_12
Patent number
US08334381B2

Reaction notes

Loading…