HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 67500936, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 5-Pyrimidinecarboxylic acid, 2-[(2-methyl-5-nitrophenyl)amino]-4-(3-pyridinyl)-, ethyl ester | HCID 59253666 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 67500936 | HCID 67500936 | 85.4% |
Reaction Steps
1.0 g ethyl 2-[(2-methyl-5-nitrophenyl)amino]-4-(3-pyridinyl)pyrimidine-5-carboxylate and 0.8 g sodium carbonate in 20 mL ethanol and 4 mL water is suspended. The mixture is refluxed for 4 hours by distillating the ethanol and compensating with water the volume loss. The mixture is cooled at room temperature, and the precipitate is filtrated, yielding 0.84 g of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08334381B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-dd3c89627a6a46599f792335ca77dfbf |
| Source note | uspto-grants-2012_12 |