Triethylamine → HCID 59254945, compound

HRID 2194991Notes

Reaction equation

HRID 2194991 reaction equation
[C:1]([C:3]1([NH2:9])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1)#[CH:2].C(N(CC)CC)C.[CH3:17][N:18]=[C:19]=[O:20]>C(#N)C>[C:1]([C:3]1([NH:9][C:19]([NH:18][CH3:17])=[O:20])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1)#[CH:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 1216911-Ethynylcyclohexylamine

Product 1

HCID 59254945HCID 59254945, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 1 g (8 mmol) 1-ethynylcyclohexylamine and 2 mL (15 mmol) triethylamine in 10 mL acetonitrile is combined at ambient temperature with 0.5 g (9 mmol) methylisocyanate. The colourless suspension is stirred overnight at ambient temperature and then evaporated down. The residue is taken up in dichloromethane and washed with aqueous potassium carbonate solution. The organic phase is dried and evaporated down. Yield: 1.4 g (colourless solid)

Workup

  1. customevaporated down
  2. washwashed with aqueous potassium carbonate solution
  3. customThe organic phase is dried
  4. customevaporated down

Sources & evidence

ORD record
ord-8c3bc1b8cbb346fd89331d9dc558d6e1
Source dataset
uspto-grants-2012_12
Patent number
US08334378B2

Reaction notes

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