HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 4-cyano-2-fluorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 4-Cyano-2-fluorobenzoic acid | HCID 590659 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | Methyl 4-cyano-2-fluorobenzoate | HCID 15278726 | — |
Reaction Steps
4-Cyano-2-fluorobenzoic acid (1 g; 6.06 mmol) was suspended in MeOH (10 mL) and 1-(3-dimethyl aminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) (1.39 g; 7.27 mmol; 1.20 eq.) and 4-dimethylaminopyridine (70 mg; 0.61 mmol; 0.10 eq.) were added. The mixture was stirred at RT overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202856B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-9a6748e283a6486098fc7ca5686636fa |
| Source note | uspto-grants-2012_06 |