Methanol → Methyl 4-cyano-2-fluorobenzoate
Reaction equation
[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[C:5]([F:12])[CH:4]=1)#[N:2].[CH3:13]O>CN(C)C1C=CN=CC=1>[CH3:13][O:8][C:7](=[O:9])[C:6]1[CH:10]=[CH:11][C:3]([C:1]#[N:2])=[CH:4][C:5]=1[F:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
4-Cyano-2-fluorobenzoic acid (1 g; 6.06 mmol) was suspended in MeOH (10 mL) and 1-(3-dimethyl aminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) (1.39 g; 7.27 mmol; 1.20 eq.) and 4-dimethylaminopyridine (70 mg; 0.61 mmol; 0.10 eq.) were added. The mixture was stirred at RT overnight.
Sources & evidence
- ORD record
- ord-9a6748e283a6486098fc7ca5686636fa
- Source dataset
- uspto-grants-2012_06
- Patent number
- US08202856B2
Reaction notes
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