反应详情

温度

120 °C

The mixture of 1.7 g of 2-amino-3-cyano-4-hydroxy-6-(2,6-dimethylmorpholin-4-yl)quinoline and 3.4 ml of phosphoryl chloride is stirred at 120° C. for 4 hours. The cooled reaction mixture is poured onto 30 g of ice, the pH of the mixture is adjusted to 8 with 10% sodium hydroxide solution, and the precipitated material is filtered off. After drying 1.5 g of the title compound is obtained (MH+: 317).

1. customThe cooled reaction mixture
2. filtrationthe precipitated material is filtered off
3. dry with materialAfter drying 1.5 g of the title compound
4. customis obtained (MH+: 317)