Benzylamine → 2-Amino-3-cyano-4-benzylamino-6-(2,6-dimethylmorpholin-4-yl)quinoline

HRID 2195690Notes

Reaction equation

HRID 2195690 reaction equation
[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N:15]3[CH2:20][CH:19]([CH3:21])[O:18][CH:17]([CH3:22])[CH2:16]3)[CH:8]=2)[N:3]=1.[CH2:23]([NH2:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>O>[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10]([NH:30][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N:15]3[CH2:20][CH:19]([CH3:21])[O:18][CH:17]([CH3:22])[CH2:16]3)[CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 670235572-Amino-3-cyano-4-chloro-6-(2,6-dimethylmorpholin-4-yl)quinoline

Product 1

HCID 670234962-Amino-3-cyano-4-benzylamino-6-(2,6-dimethylmorpholin-4-yl)quinoline

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3 g of 2-amino-3-cyano-4-chloro-6-(2,6-dimethylmorpholin-4-yl)quinoline and 6 ml of benzylamine are stirred at 125° C. for 3 hours. The reaction mixture is poured onto 30 ml of water. The precipitated material is filtered off, washed with 20 ml of water. After drying 2.3 g of the title compound is obtained (MH+: 388).

Workup

  1. filtrationThe precipitated material is filtered off
  2. washwashed with 20 ml of water
  3. dry with materialAfter drying 2.3 g of the title compound
  4. customis obtained (MH+: 388)

Sources & evidence

ORD record
ord-6df2d67a79ee41a09906c20d92d90acf
Source dataset
uspto-grants-2012_12
Patent number
US08338411B2

Reaction notes

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