HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → 2-Amino-3-cyano-4-benzylamino-6-(2,6-dimethylmorpholin-4-yl)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | 2-Amino-3-cyano-4-chloro-6-(2,6-dimethylmorpholin-4-yl)quinoline | HCID 67023557 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Amino-3-cyano-4-benzylamino-6-(2,6-dimethylmorpholin-4-yl)quinoline | HCID 67023496 | — |
Reaction Steps
3 g of 2-amino-3-cyano-4-chloro-6-(2,6-dimethylmorpholin-4-yl)quinoline and 6 ml of benzylamine are stirred at 125° C. for 3 hours. The reaction mixture is poured onto 30 ml of water. The precipitated material is filtered off, washed with 20 ml of water. After drying 2.3 g of the title compound is obtained (MH+: 388).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338411B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-6df2d67a79ee41a09906c20d92d90acf |
| Source note | uspto-grants-2012_12 |