HuagongsheHuagongshe Chemistry Print Report · For research reference only
Amino 4-methylbenzene-1-sulfonate → HCID 86644593, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Amino 4-methylbenzene-1-sulfonate | HCID 10965249 | — |
| Reactant | 2-Amino-3-cyano-4-benzylamino-6-(2,6-dimethylmorpholin-4-yl)quinoline | HCID 67023496 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86644593 | HCID 86644593 | — |
Reaction Steps
To the solution of 3.2 g of 2-amino-3-cyano-4-benzylamino-6-(2,6-dimethylmorpholin-4-yl)quinoline in 20 ml dimethylformamide, 2.2 g of O-tosylhydroxylamine in 25 ml dichloromethane is dropped at 20° C. in 15 minutes. After 5 hours of stirring the precipitated crystalline material is filtered off. After drying 3.4 g of the title compound is obtained (MH+:403).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338411B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-162e441f075342d88895a055baf3ac58 |
| Source note | uspto-grants-2012_12 |