HRID2195691

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10965249

Amino 4-methylbenzenesulfonate

C7H9NO3S

结构：CC1CN(c2ccc3nc(N)c(C#N)c(NCc4ccccc4)c3c2)CC(C)O1

HCID67023496

未命名化合物

PRODUCTS

生成物

结构：CC1CN(c2ccc3c(c2)c(NCc2ccccc2)c(C#N)c(N)[n+]3N)CC(C)O1.Cc1ccc(S(=O)(=O)[O-])cc1

HCID86644593

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To the solution of 3.2 g of 2-amino-3-cyano-4-benzylamino-6-(2,6-dimethylmorpholin-4-yl)quinoline in 20 ml dimethylformamide, 2.2 g of O-tosylhydroxylamine in 25 ml dichloromethane is dropped at 20° C. in 15 minutes. After 5 hours of stirring the precipitated crystalline material is filtered off. After drying 3.4 g of the title compound is obtained (MH+:403).

WORKUP

后处理

filtrationis filtered off
dry with materialAfter drying 3.4 g of the title compound
customis obtained (MH+:403)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-162e441f075342d88895a055baf3ac58
来源数据集: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08338411B2
来源说明: uspto-grants-2012_12

反应 SMILES

[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10]([NH:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N:22]3[CH2:27][CH:26]([CH3:28])[O:25][CH:24]([CH3:29])[CH2:23]3)[CH:8]=2)[N:3]=1.[S:30]([O:40][NH2:41])([C:33]1[CH:39]=[CH:38][C:36]([CH3:37])=[CH:35][CH:34]=1)(=[O:32])=[O:31]>CN(C)C=O.ClCCl>[S:30]([C:33]1[CH:39]=[CH:38][C:36]([CH3:37])=[CH:35][CH:34]=1)([O-:40])(=[O:32])=[O:31].[NH2:41][N+:3]1[C:4]2[C:9](=[CH:8][C:7]([N:22]3[CH2:23][CH:24]([CH3:29])[O:25][CH:26]([CH3:28])[CH2:27]3)=[CH:6][CH:5]=2)[C:10]([NH:14][CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[C:11]([C:12]#[N:13])[C:2]=1[NH2:1]