HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diphosgene → 5-(4-Acetylpiperazin-1-yl)isatoic anhydride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diphosgene | HCID 10426 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 2-Amino-5-(4-acetylpiperazin-1-yl)benzoic acid | HCID 49966140 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-(4-Acetylpiperazin-1-yl)isatoic anhydride | HCID 86644595 | — |
Reaction Steps
To the mixture of 18 g 2-amino-5-(4-acetylpiperazin-1-yl)benzoic acid and 60 ml dioxane, 10 ml diphosgene is added dropwise under stirring and cold water cooling. The mixture is then heated at reflux temperature for 2 hours. After cooling the solid material is filtered off, washed with 50 ml ether and dried. 24 g of the title compound is obtained (MH+: 290).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338411B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-2ea3c469df114606936ba4bc94061de5 |
| Source note | uspto-grants-2012_12 |