反应详情

To the mixture of 18 g 2-amino-5-(4-acetylpiperazin-1-yl)benzoic acid and 60 ml dioxane, 10 ml diphosgene is added dropwise under stirring and cold water cooling. The mixture is then heated at reflux temperature for 2 hours. After cooling the solid material is filtered off, washed with 50 ml ether and dried. 24 g of the title compound is obtained (MH+: 290).

1. additionis added dropwise
2. temperatureThe mixture is then heated
3. temperatureat reflux temperature for 2 hours
4. temperatureAfter cooling the solid material
5. filtrationis filtered off
6. washwashed with 50 ml ether
7. customdried