反应详情

The mixture of 1.7 g 2-amino-3-cyano-4-hydroxy-6-(4-acetylpiperazin-1-yl)quinoline, 50 ml acetonitrile and 3.4 ml phosphoryl chloride is heated at reflux temperature for 4 hours. The cooled reaction mixture is poured onto 30 g ice, the pH of the mixture is set to 8 with 10% sodium hydroxide solution and the resulting precipitate is filtered off. After drying 1.5 g of the title compound is obtained (MH+: 330).

1. temperatureis heated
2. temperatureat reflux temperature for 4 hours
3. customThe cooled reaction mixture
4. filtrationthe resulting precipitate is filtered off
5. dry with materialAfter drying 1.5 g of the title compound
6. customis obtained (MH+: 330)