Benzylamine → 2-Amino-3-cyano-4-benzylamino-6-(4-acetylpiperazin-1-yl)quinoline

HRID 2195696Notes

Reaction equation

HRID 2195696 reaction equation
[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N:15]3[CH2:20][CH2:19][N:18]([C:21](=[O:23])[CH3:22])[CH2:17][CH2:16]3)[CH:8]=2)[N:3]=1.[CH2:24]([NH2:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>O>[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10]([NH:31][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N:15]3[CH2:20][CH2:19][N:18]([C:21](=[O:23])[CH3:22])[CH2:17][CH2:16]3)[CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 670236312-Amino-3-cyano-4-chloro-6-(4-acetylpiperazin-1-yl)quinoline

Product 1

HCID 670236072-Amino-3-cyano-4-benzylamino-6-(4-acetylpiperazin-1-yl)quinoline

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5 g 2-amino-3-cyano-4-chloro-6-(4-acetylpiperazin-1-yl)quinoline and 15 ml benzylamine is stirred at 125° C. for 1 h. The reaction mixture is then poured onto 30 ml water, the resulting precipitate is filtered off, washed with 20 ml water and dried to obtain 4 g of the title compound (MH+: 401).

Workup

  1. filtrationthe resulting precipitate is filtered off
  2. washwashed with 20 ml water
  3. customdried

Sources & evidence

ORD record
ord-a05e7042b25243dcb60cf2c296ed5ae9
Source dataset
uspto-grants-2012_12
Patent number
US08338411B2

Reaction notes

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