HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → 2-Amino-3-cyano-4-benzylamino-6-(4-acetylpiperazin-1-yl)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | 2-Amino-3-cyano-4-chloro-6-(4-acetylpiperazin-1-yl)quinoline | HCID 67023631 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Amino-3-cyano-4-benzylamino-6-(4-acetylpiperazin-1-yl)quinoline | HCID 67023607 | — |
Reaction Steps
5 g 2-amino-3-cyano-4-chloro-6-(4-acetylpiperazin-1-yl)quinoline and 15 ml benzylamine is stirred at 125° C. for 1 h. The reaction mixture is then poured onto 30 ml water, the resulting precipitate is filtered off, washed with 20 ml water and dried to obtain 4 g of the title compound (MH+: 401).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338411B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-a05e7042b25243dcb60cf2c296ed5ae9 |
| Source note | uspto-grants-2012_12 |