Amino 4-methylbenzene-1-sulfonate → 1-Amino-2-(3-methoxybenzoylamino)-3-cyano-4-benzylamino-6-(4-acetylpiperazin-1-yl)quinolinium tosylate

Participants

Reaction Steps

To the solution of 0.72 g 3-methoxy-N-[6-(4-acetylpiperazin-1-yl)-4-benzylamino-3-cyanoquinolin-2-yl]benzamide in 20 ml dimethylformamide, 0.6 g of O-tosylhydroxylamine in 25 ml dichloromethane is added dropwise at 20° C. in 15 minutes. After 5 hours of stirring the precipitated crystalline material is filtered off. After drying 0.65 g of the title compound is obtained (MH+: 551).

Provenance & Evidence