HRID2195698

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10965249

Amino 4-methylbenzenesulfonate

C7H9NO3S

结构：COc1cccc(C(=O)Nc2nc3ccc(N4CCN(C(C)=O)CC4)cc3c(NCc3ccccc3)c2C#N)c1

HCID67023658

未命名化合物

PRODUCTS

生成物

结构：COc1cccc(C(=O)Nc2c(C#N)c(NCc3ccccc3)c3cc(N4CCN(C(C)=O)CC4)ccc3[n+]2N)c1.Cc1ccc(S(=O)(=O)[O-])cc1

HCID86644596

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To the solution of 0.72 g 3-methoxy-N-[6-(4-acetylpiperazin-1-yl)-4-benzylamino-3-cyanoquinolin-2-yl]benzamide in 20 ml dimethylformamide, 0.6 g of O-tosylhydroxylamine in 25 ml dichloromethane is added dropwise at 20° C. in 15 minutes. After 5 hours of stirring the precipitated crystalline material is filtered off. After drying 0.65 g of the title compound is obtained (MH+: 551).

WORKUP

后处理

filtrationis filtered off
dry with materialAfter drying 0.65 g of the title compound
customis obtained (MH+: 551)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7481a9ac22a44dd68feea6e908346c39
来源数据集: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08338411B2
来源说明: uspto-grants-2012_12

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:38]=[CH:39][CH:40]=1)[C:6]([NH:8][C:9]1[C:18]([C:19]#[N:20])=[C:17]([NH:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([N:29]3[CH2:34][CH2:33][N:32]([C:35](=[O:37])[CH3:36])[CH2:31][CH2:30]3)[CH:15]=2)[N:10]=1)=[O:7].[S:41]([O:51][NH2:52])([C:44]1[CH:50]=[CH:49][C:47]([CH3:48])=[CH:46][CH:45]=1)(=[O:43])=[O:42]>CN(C)C=O.ClCCl>[S:41]([C:44]1[CH:50]=[CH:49][C:47]([CH3:48])=[CH:46][CH:45]=1)([O-:51])(=[O:43])=[O:42].[NH2:52][N+:10]1[C:11]2[C:16](=[CH:15][C:14]([N:29]3[CH2:30][CH2:31][N:32]([C:35](=[O:37])[CH3:36])[CH2:33][CH2:34]3)=[CH:13][CH:12]=2)[C:17]([NH:21][CH2:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)=[C:18]([C:19]#[N:20])[C:9]=1[NH:8][C:6](=[O:7])[C:5]1[CH:38]=[CH:39][CH:40]=[C:3]([O:2][CH3:1])[CH:4]=1