HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 178427653, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Amino 4-methylbenzene-1-sulfonate | HCID 10965249 | — |
| Reactant | 2-Amino-3-cyano-4-hydroxy-6-iodoquinoline | HCID 178510457 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178427653 | HCID 178427653 | 57.4% |
Reaction Steps
0.62 g of 2-amino-3-cyano-4-hydroxy-6-iodoquinoline is stirred for 40 minutes in 10 ml dimethylformamide in the presence of 1 g solid potassium carbonate, then the solution of 0.6 g O-tosyl-hydroxylamine in 14 ml dichloromethane is added dropwise. After stirring the reaction mixture at room temperature for 4 hours, the precipitated solid material is filtered off and dried to obtain 0.57 g of the title compound (MH+: 327).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338411B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-26e51f8937f34a5fa5fdd80472c2bc2c |
| Source note | uspto-grants-2012_12 |