HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 178427653, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Amino 4-methylbenzene-1-sulfonate | HCID 10965249 | — |
| Reactant | 2-Amino-3-cyano-4-hydroxy-6-iodoquinoline | HCID 178510457 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178427653 | HCID 178427653 | 57.4% |
Reaction Steps
0.62 g 2-amino-3-cyano-4-hydroxy-6-iodoquinoline in 10 ml of dimethylformamide is stirred with 1 g of solid potassium carbonate for 40 minutes. Then, 0.6 g O-tosylhydroxylamine in 14 ml dichloromethane is added dropwise to the reaction mixture. Stirring at room temperature is continued for 4 hours. The precipitated crystalline material is filtered off and dried to obtain 0.57 g of the title compound (MH+: 327).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338411B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-bb1cd1922ef3471c93f9f2b16869338f |
| Source note | uspto-grants-2012_12 |